Population
Co-cultures of bovine aortic endothelial cells and bovine smooth muscle cells, and co-cultures of human…
Comparison
Addition of Lipoprotein (Lp) and plasminogen to… vs Addition of LDL or control conditions without Lp
Design
Preclinical
Authors
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May link Lp(a) to atherogenesis via TGF-beta; leaves open relevance in human disease.
Lp(a) inhibits the activation of TGF-beta, an endogenous inhibitor of smooth muscle cell migration, suggesting a mechanism by which high Lp(a) levels contribute to atheromatous lesion generation.
Kojima et al. (1991) studied this question.
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