Crystallization is one of the most frequently utilized separation operations in the pharmaceutical industry as a purification step and for producing a solid product with a desired particle size distribution. This crystallization or precipitation is often effected by the addition of a miscible nonsolvent that drastically reduces the solubility of the solute in the mixture. In order to characterize the important phenomena in the crystallization of molecules that have biological significance, we have studied the fundamentals of the crystallization of biochemicals by nonsolvent addition using a model system: the crystallization of amino acids from mixtures of water and aliphatic alcohols.
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Orella et al. (1989) studied this question.
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