Why the study?
Understanding the effect of statins on epicardial adipose tissue is important because reducing EAT-derived molecules may mitigate their negative cardiovascular impacts.
Does statin therapy reduce epicardial adipose tissue in patients?
Does statin therapy reduce epicardial adipose tissue in patients?
Statin therapy is associated with a significant reduction in epicardial adipose tissue, suggesting a potential pleiotropic cardiovascular benefit beyond lipid lowering.
May offer additional CV protection via EAT reduction; strengthens evidence for statin pleiotropy from three RCTs.
Introduction Understanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT. Methods The study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5th, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software. Results In the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = –0.507, 95% CI: –2.536, 1.521, p = 0.021). Conclusions Statins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.
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Jamialahmadi et al. (2024) studied this question.
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