Lesional skin specimens from scleroderma patients were sliced horizontally into three layers. The ratio of hyaluronic acid to dermatan sulfate in each layer was analyzed. The ratios in each layer of scleroderma skin were lower than those in the corresponding layers of normal skin and the lowest value was found in the bottom layer of scleroderma skin. The possible involvement of glycosaminoglycan metabolism in the pathophysiology of scleroderma is discussed.
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Tajima et al. (1982) studied this question.
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