Why the study?
Does the source of increased respiratory drive (voluntary vs involuntary) differentially affect the activation of the costal and crural diaphragm in healthy humans?
Does the source of increased respiratory drive (voluntary vs involuntary) differentially affect the activation of the costal and crural diaphragm in healthy humans?
When stimulated by either a voluntary or involuntary drive to breathe above tidal volume, the neural drive to the diaphragm is greater to the costal than the crural portion.
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Costal-crural dissociation at high drive warrants caution in interpreting global diaphragm EMG; leaves open its role in disease-related ventilatory failure.
Simultaneous electromyographic recordings from the human costal and crural diaphragm during voluntary augmented breathing and involuntary rebreathing show that the increase in inspiratory crural diaphragm activity was ~60% of the increase in costal diaphragm activity. However costal to crural diaphragm activation did not differ between the two tasks. The dissociation in the amplitude of activation of the costal and crural diaphragm becomes apparent only as the drive to breathe increases above tidal breathing.
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Nguyen et al. (2020) studied this question.
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