The problem confronting the pediatrician who considers the use of ACTH and cortisone in treatment of a patient is considered. Serious untoward side reactions observed in the treatment of 340 children with ACTH and adrenocortical hormones are documented. Potential hazards of treatment with ACTH and adrenocortical hormones, not yet expressed clinically, are indicated. The implications of these observations in the use of ACTH and steroid hormones in clinical pediatrics are considered.
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Good et al. (1957) studied this question.