Lamotrigine oxoanalog 8 was prepared using 5-(2-amino-5,6-dichlorophenyl)-6-azauracil 3 as starting compound.A series of 5-(2,3-dichlorophenyl)-6-azauracil derivatives 9-12 with additional substituents in the benzene ring were synthesized as well.The conversion of hydrazone 13 to derivative 14 containing two 6-azauracil rings is also described.
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Hlaváč et al. (2003) studied this question.