Pathogenesis of the nitrogen dioxide-induced lesion in the rat lung: a review and presentation of new observations.

Gustave Freeman; Sheldon C. Crane; Robert J. Stephens; N. J. Furiosi

doi:10.1164/arrd.1968.98.3.429

September 1, 1968

Pathogenesis of the nitrogen dioxide-induced lesion in the rat lung: a review and presentation of new observations.

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Key Points

To review known mechanisms and characterize new pathological changes in rat lungs following subacute and chronic nitrogen dioxide exposure.
Examined pathological lung outcomes in rats exposed to subacute nitrogen dioxide concentrations (10 to 25 ppm).
Assessed chronic pulmonary structural changes in rats subjected to lifetime nitrogen dioxide exposure (2 ± 1 ppm).
Concentrations of 10 to 25 ppm nitrogen dioxide induced increased lung weight and air retention driven by respiratory epithelial hypertrophy in terminal bronchioles and alveoli, without causing edema or necrosis.
Lifetime exposure to 2 ± 1 ppm nitrogen dioxide did not produce emphysema, but caused loss of bronchiolar cilia, impaired epithelial exfoliation and blebbing, and generated cytoplasmic crystalloid inclusions.

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Implication

Experimental study reveals epithelial hypertrophy and ciliary loss in rat lungs after nitrogen dioxide exposure, suggesting chronic structural remodeling without overt emphysema.

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Freeman et al. (1968) studied this question.

synapsesocial.com/papers/6a726fc5e36a167817e3de20 https://doi.org/10.1164/arrd.1968.98.3.429

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Pathogenesis of the nitrogen dioxide-induced lesion in the rat lung: a review and presentation of new observations.

Key Points

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Pathogenesis of the nitrogen dioxide-induced lesion in the rat lung: a review and presentation of new observations.

Key Points

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Implication

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