Strongly Binding Cell‐Adhesive Polypeptides of Programmable Valencies

Longer and stronger: Engineered multivalent polypeptides were used to increase and tune the adhesion strength of cells to surfaces. Monodisperse polypeptides containing programmable valencies of a cell-adhesion sequence were synthesized (with up to 80 repeats of the RGD sequence; see schematic illustration). The multivalent cell-adhesion polypeptides provided strong resistance to cellular delamination under shear.