Lipoid Nephrosis

In the last ten years a tremendous amount of literature on lipoid nephrosis has been published. Since 1918 we have been carefully observing and following up children with lipoid nephrosis. Our first observations were published in 1922¹and 1929.²It is not our intention to give an exhaustive treatise on the subject in this paper. Recently, Leiter³reviewed extensively the subject of lipoid nephrosis both in children and in adults. In this communication we wish to consider certain aspects of this condition, the significance of which can be understood only by the study of patients who have been under continuous observation for a prolonged period. Our primary purpose is to consider the prognosis. Secondarily, the final diagnosis will be considered because it is our impression that in certain cases only after prolonged observation or necropsy can a positive diagnosis be established. A typical case is characterized chiefly