Parenchymatous Nephritis

In this paper, evidence that infection of the paranasal sinuses may play an important etiologic rôle in parenchymatous nephritis will be presented. The evidence consists in the demonstration that: (1) such infection was invariably present in each of a series of unselected cases; (2) exacerbations of the infection were accompanied by exaggeration of the symptoms; (3) successful treatment of the infection was followed by improvement or cure; (4) other forms of treatment were of temporary benefit only; (5) in other forms of nephritis, sinusitis is not regularly present. The nature of parenchymatous nephritis has been more fully discussed in the preceding paper.¹Renal lesions in parenchymatous nephritis are confined to the kidney tubules. We believe, however, that the disease affects the whole body, not merely the kidney, and that one of its important consequences is a decreased resistance to infection of all sorts. This susceptibility to infection tends to