INTRODUCTION Tepperman, Engel and Long (1943) have reviewed the literature concerning adrenal hypertrophy and have pointed out the factors which lead to cortical atrophy. Clinical studies by Albright, Reifenstein and Forbes (1946) have shown that the administration of methyl testosterone reduces the urinary excretion of 17-ketosteroids and 11- oxysteroids in normal women and patientswith adrenogenital syndrome. They pointed out the desirability of obtaining a steroid which would “inhibit the androgenous source without itself being an androgen.” The ultimate pupose of this investigation was to find a substance which might in such a manner control congenital hyperplasia of the adrenal in females. The effect of 17-vinyl testosterone and of other androgenic and non-androgenic steroids was investigated. Studies were made of the weight and cholesterol concentration of the adrenals of male and female rats treated with these steroids. In addition, the role of the gonads and the pituitary was studied by administering the compounds to gonadectomized and hypophysectomized animals.
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Lewis et al. (1949) studied this question.