Ein neuer Zugang zu 2′‐O‐(2‐Methoxyethyl)ribonucleosiden ausgehend von D‐Glucose

A New Access to 2′‐ O ‐(2‐Methoxyethyl)ribonucleosides Starting from D ‐Glucose A new synthesis of 2′‐ O ‐(2‐methoxyethyl)ribonucleosides, building blocks for second‐generation antisense oligonucleotides, starting from D ‐glucose is presented. The key‐step is the transformation of 3‐ O ‐methoxyethylallofuranose to 2‐ O ‐(2‐methoxyethyl)ribose by NaIO 4 oxidation. Together with the 4′‐phenylbenzoyl protecting group, which results in crystalline intermediates, this synthesis provides an easy and cheap access to 2′‐ O ‐(2‐methoxyethyl)‐substituted ribonucleosides.