Inhibition of expression of human immunodeficiency virus-1 in vitro by antibody-targeted liposomes containing antisense RNA to the env region.

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Why the study?

Does antibody-targeted liposome-encapsulated antisense env RNA inhibit HIV-1 production in infected H9 cells?

Structured PICO

Does antibody-targeted liposome-encapsulated antisense env RNA inhibit HIV-1 production in infected H9 cells?

Population

HIV-1-infected H9 cells (HTLV-IIIB/H9 system in vitro)

Intervention

Viral env region antisense RNA encapsulated in liposomes targeted by antibodies specific for the T cell receptor molecule CD3

Comparator

Sense env RNA, pol RNA (sense or antisense), env region antisense RNA free in solution, or encapsulated in liposomes without targeting antibody

Outcome

HIV-1 productionsurrogate

Antibody-targeted liposomes delivering antisense env RNA effectively inhibit HIV-1 viral protein production at the translational level in vitro.

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Supports preclinical development of targeted antisense delivery for HIV; leaves open translation to in vivo or clinical settings.

Renneisen et al. (1990) studied this question.

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