Effectiveness of vortioxetine in patients with major depressive disorder comorbid with generalized anxiety disorder: Results of the RECONNECT study

Figures

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  Figure 1.. Panels (a) to (e): LS mean (SE) change from baseline for (a) MADRS total score, (b) HAM-A total score, (c) HADS-D subscale score, (d) HADS-A subscale score and (e) CGI-S score; panel (f): LS mean (SE) CGI-I score (full analysis set). For panels (a) to (e), p-values are at week 8 vs baseline; for panel (f), p-value is at week 8 based on a test of CGI-I score = 4 (no improvement). CGI-I: Clinical Global Impression–Improvement; CGI-S: Clinical Global Impression–Severity; HADS-A: Hospital Anxiety and Depression Scale–Anxiety; HADS-D: Hospital Anxiety and Depression Scale–Depression; HAM-A: Hamilton Anxiety Rating Scale; LS: least-squares; MADRS: Montgomery–Åsberg Depression Rating Scale; SE: standard error.

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  Figure 2.. FAST total and domain scores at baseline and change (SE) from baseline after 8 weeks of treatment with vortioxetine (full analysis set; patients with a corresponding baseline score). p < 0.0001 for all changes from baseline. FAST: Functioning Assessment Short Test; CFB: change from baseline; SE: standard error.

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  Figure 3.. Q-LES-Q long-form domain scores at baseline and change (SE) from baseline after 8 weeks of treatment with vortioxetine (full analysis set, patients with a corresponding baseline score). The Q-LES-Q numerical scale has been converted into a percentage scale by linear transformation of the scores into a scale of 0–100, where 0 corresponds to the worst score and 100 to the best score on the numerical scale. p < 0.0001 for all changes from baseline. CFB: change from baseline; Q-LES-Q long-form: Quality of Life Enjoyment and Satisfaction Questionnaire long-form; SE: standard error.