Highly purified substance P preparations were infused intravenously in doses of 0.2‐1.2 units per kg body weight per min in six healthy subjects. Red flushing, tachycardia and a rapid fall in arterial blood pressure were observed. Cardiac output was slightly increased. The effects were maximal after 1–2 min and gradually decreased during continued infusion.
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Dunér et al. (1960) studied this question.
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