Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has rapidly swept through the worldwide, with more than 3 million confirmed cases. Until now, no vaccine or effective therapeutic measures are provided to prevent the SARS-CoV-2 infection. Existing medicines have some strong advantages on pharmacokinetics, known side effects, safety and dosing regimens. 1 Although remdesivir and chloroquine could effectively inhibit the replication of SARS-CoV-2 in vitro, 2 no medicine candidates have been evaluated in vivo by using animal models with SARS-CoV-2 infection.
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Deng et al. (2020) studied this question.
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