Why the study?
Massive biventricular thrombi associated with myocarditis are rare and pose significant management challenges.
Does multidisciplinary therapy including anticoagulation and GDMT improve thrombus resolution and cardiac function in a patient with massive biventricular thrombi associated with myocarditis?
Does multidisciplinary therapy including anticoagulation and GDMT improve thrombus resolution and cardiac function in a patient with massive biventricular thrombi associated with myocarditis?
Medical therapy with anticoagulation and GDMT can successfully resolve massive biventricular thrombi and improve cardiac function in patients with myocarditis.
Supports medical management of rare giant biventricular thrombi; leaves open need for prospective validation before broader adoption.
Background: Massive biventricular thrombi associated with myocarditis are rare and pose significant management challenges. Case presentation: A 24-year-old male from a plateau region presented with dyspnea, chest pain, and cerebral infarction/hemorrhage. Imaging revealed giant biventricular thrombi (left: 81 × 62 × 59 mm; right: 59 × 16 mm) and LVEF of 25%. Management: Multidisciplinary therapy included anticoagulation and GDMT. Outcomes: Complete thrombus resolution occurred by 10 weeks, with improved cardiac function (LVEF 48%) and no recurrent embolism. Conclusion: Drug therapy may be effective for massive biventricular thrombi in myocarditis.
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Liang et al. (2025) studied this question.
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