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June 1, 2021Journal of Medical Microbiology and Infectious DiseasesOpen Access

In-silico Immunomodelling of SARS-CoV-2

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Authors

AMAmirhosein MaaliHTHossein TeimouriMAMehdi Azad

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Overview

Computational comparative analysis reveals reduced proteasomal processing and fewer B-cell epitopes in SARS-CoV-2 versus SARS-CoV, suggesting distinct immune evasion strategies.

Key Points

  • To characterize and compare major structural proteins of SARS-CoV-2 and SARS-CoV to predict antigen proteasomal cleavage, MHC class I presentation, and immune epitope profiles.
  • Retrieved amino acid sequences for spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins from NCBI, followed by alignment via MEGA 7.0 and structural modeling via SWISS-MODEL.
  • Predicted proteasomal cleavage, MHC class I processing, and T-cell epitopes using IEDB and EPISOFT, B-cell epitopes via BepiPred 2.0, and anti-inflammatory epitopes via AntiInflam.
  • SARS-CoV-2 S glycoprotein and M glycoprotein showed 26.57% and 20.59% lower efficiency in proteasomal cleavage and MHC class I presentation compared to SARS-CoV, respectively.
  • Fewer B-cell epitopes were predicted across SARS-CoV-2 viral proteins compared to SARS-CoV.

Cite This Study

Maali et al. (2021) studied this question.

synapsesocial.com/papers/6a7285b035aa2c282ce34be8https://doi.org/10.52547/jommid.9.2.88
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