Abstract 1. Children with both kwashiorkor and megaloblastic anemia when first tested excreted urocanic acid in their urine but no formimino glutamic acid (FIGLU). 2. Treatment with a high protein diet eliminated the block in urocanic acid metabolism. Urocanic acid was no longer excreted and the expected abnormal FIGLU appeared in the urine. 3. Treatment with PGA, but not vitamin B12, corrected the second metabolic block. The excretion of FIGLU stopped and the bone marrow became normoblastic.
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Allen et al. (1965) studied this question.
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