Of Diuretics, Transporters, and Mechanisms of Hypertension

February 1, 2026Seminars in NephrologyOpen Access

View Full Paper

Ask AI

Bookmark

Share

Key Points

To review three decades of scientific progress in renal salt transport physiology and pathophysiology spurred by the pioneering cloning of membrane transporter genes.
Narrative historical review tracing the molecular physiology program established at Brigham and Women's Hospital in the 1980s.
Synthesis of cDNA cloning breakthroughs for kidney solute transporters, ion channels, and receptors alongside their regulatory roles in blood pressure.
Highlights the initial cloning of key transport proteins, including the renal sodium-chloride cotransporter, sodium-potassium-chloride cotransporter, ROMK potassium channel, and calcium-sensing receptor.
Documents how characterization of these transport systems established the modern molecular mechanisms underlying diuretic efficacy and hypertensive pathology.

Design

Review

These cloning milestones underpin current renal transporter-targeted therapies; leaves open identification of novel cardiorenal drug targets.

No abstract yet. The journal hasn't published one we can show.

No takes yet. Share an insight, caveat, or question.

Castañeda‐Bueno et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Share