Why the study?
Do anti-Xa, anti-IIa activities, APTT, and D-dimers correlate with thrombosis and haemorrhage in patients receiving LMWH (tinzaparin or enoxaparin) after total hip replacement?
Population
440 patients undergoing total hip replacement
Comparison
Tinzaparin 4500 anti-Xa IU subcutaneously once… vs Enoxaparin 40 mg subcutaneously once daily
Design
RCT, randomized, double-blind
Follow-up
14 days
Authors
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Routine monitoring of anti-Xa, anti-IIa, APTT or D-dimers is not supported post-hip replacement on LMWH; challenges their predictive utility for thrombosis or bleeding.
Do anti-Xa, anti-IIa activities, APTT, and D-dimers correlate with thrombosis and haemorrhage in patients receiving LMWH (tinzaparin or enoxaparin) after total hip replacement?
In patients undergoing total hip replacement receiving LMWH, routine monitoring of anti-Xa, anti-IIa activities, APTT, or D-dimers does not predict clinical outcomes of thrombosis or hemorrhage.
Bara et al. (1999) studied this question.
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