Key result
Vitamin D and sphingolipids exhibit mutual physiological crosstalk in cardiometabolic disease pathogenesis.
Review reveals bidirectional crosstalk between vitamin D and sphingolipids, highlighting therapeutic implications for cardiometabolic diseases.
Sphingolipids (SLs) are structural, bioactive molecules with several key cellular roles, whereas 1,25-dihydroxyvitamin D (1,25(OH)D), the active form of vitamin D, is considered the major regulator of calcium homeostasis, although it also exerts other extraskeletal effects. Many studies reported the physiological connection between vitamin D and SLs, highlighting not only the effects of vitamin D on SL metabolism and signaling but also the influence of SLs on vitamin D levels and function, thus strongly suggesting a crosstalk between these molecules. After a brief description of 1,25(OH)D and SL metabolism, this review aims to discuss the preclinical and clinical evidence on the crosstalk between SLs and 1,25(OH)D, with a special focus on cardiometabolic diseases.
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Fenizia et al. (2023) conducted a review in Cardiometabolic diseases. Vitamin D (1,25-dihydroxyvitamin D) and Sphingolipids was evaluated. Vitamin D (1,25(OH)D) and sphingolipids exhibit mutual physiological crosstalk in preclinical and clinical studies of cardiometabolic diseases (narrative review; no quantitative estimates reported).
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