Clinical Use of Cold Precipitated Antihemophilic Globulin (Factor VIII, CPAG)

A fibrinogen fraction separated from fresh frozen plasma by slow thawing at 2 C contains Factor VIII activity. The administration of this material to six patients with hemophilia A resulted in partial to complete correction of their clotting defect. Clinical hemostasis was associated with these infusions. Normal or higher than normal levels of Factor VIII were observed in one patient given this material in connection with surgery. Side effects did not occur during or after the administration of the fraction. The preparation of this material is simple and can be carried out as a routine procedure in blood banks processing large amounts of fresh frozen plasma.