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A 2‐unsubstituted indole adds under Cu‐box‐catalysis to mesoxalic ester amides with high enantioselectivity, whereas low enantiomeric excess is obtained for 2‐substituted indoles. A mesoxalic ester amide is used as key component in the total syntheses of alkaloids cladoniamide G and cladoniamide F. The natural product syntheses involve Suzuki cross‐coupling to a 2,2′‐biindole, arylation of the vic ‐tricarbonyl compound, and intramolecular lactam formation.
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Schütte et al. (2014) studied this question.
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