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Highlights the potential of harnessing antiplatelet drugs to disrupt the nexus between Aβ-induced activated platelets and Aβ fibril formation in Alzheimer's disease.
In this issue of Science Signaling, Donner et al define a highly interesting role for platelets in mediating the pathogenesis of Alzheimer's disease via a mechanism linked to integrin αIIbβ3 outside-in signaling and adenosine diphosphate release. These findings raise the intriguing prospect of harnessing antiplatelet drugs for disrupting the nexus between Aβ-induced activated platelets and Aβ fibril and aggregate formation.
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McFadyen et al. (2016) studied this question.
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