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Editorial
This editorial discusses the role and evidence surrounding screening electrocardiography in asymptomatic adults.
Editorials20 September 2011What Now With Screening Electrocardiography?Michael S. Lauer, MDMichael S. Lauer, MDFrom National Heart, Lung, and Blood Institute, Bethesda, MD 20892.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-6-201109200-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Fifty years ago in these pages, Kannel and colleagues (1) presented Framingham Heart Study data on “factors of risk” for coronary heart disease. Thirteen years earlier, the National Institutes of Health established an epidemiologic cohort study in Framingham, Massachusetts, in partial response to an epidemic of cardiovascular disease. Kannel and colleagues enrolled 5127 adults between the ages of 30 and 62 years who were free of coronary heart disease. During 6 years of follow-up, 186 men and women developed disease. The authors found that elevated blood pressure, elevated cholesterol concentration, and electrocardiographic evidence of left ventricular hypertrophy were strong independent ...References1. Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes J. Factors of risk in the development of coronary heart disease—six year follow-up experience. The Framingham Study. Ann Intern Med. 1961;55:33-50. [PMID: 13751193] LinkGoogle Scholar2. U.S. Preventive Services Task Force. Screening for high blood pressure: U.S. Preventive Services Task Force reaffirmation recommendation statement. Ann Intern Med. 2007;147:783-6. [PMID: 18056662] LinkGoogle Scholar3. U.S. Preventive Services Task Force. Screening for Lipid Disorders in Adults. Rockville, MD: U.S. Preventive Services Task Force; 2008. Accessed at www.uspreventiveservicestaskforce.org/uspstf/uspschol.htm on 10 August 2011. Google Scholar4. Chou R, Arora B, Dana T, Fu R, Walker M, Humphrey L. Screening asymptomatic adults with resting or exercise electrocardiography: a review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2011;155:375-85. LinkGoogle Scholar5. U.S. Preventive Services Task Force. Screening for coronary heart disease: recommendation statement. Ann Intern Med. 2004;140:569-72. [PMID: 15068986] LinkGoogle Scholar6. Nelson HD, Tyne K, Naik A, Bougatsos C, Chan BK, Humphrey L; U.S. Preventive Services Task Force. Screening for breast cancer: an update for the U.S. Preventive Services Task Force. Ann Intern Med. 2009;151:727-37, W237-42. [PMID: 19920273] LinkGoogle Scholar7. Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al; National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395-409. [PMID: 21714641] CrossrefMedlineGoogle Scholar8. Fleming C, Whitlock EP, Beil TL, Lederle FA. Screening for abdominal aortic aneurysm: a best-evidence systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2005;142:203-11. [PMID: 15684209] LinkGoogle Scholar9. Buys SS, Partridge E, Black A, Johnson CC, Lamerato L, Isaacs C, et al; PLCO Project Team. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA. 2011;305:2295-303. [PMID: 21642681] CrossrefMedlineGoogle Scholar10. Woods WG, Gao RN, Shuster JJ, Robison LL, Bernstein M, Weitzman S, et al. Screening of infants and mortality due to neuroblastoma. N Engl J Med. 2002;346:1041-6. [PMID: 11932470] CrossrefMedlineGoogle Scholar11. Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, et al; DIAD Investigators. Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA. 2009;301:1547-55. [PMID: 19366774] CrossrefMedlineGoogle Scholar12. Lord SJ, Irwig L, Simes RJ. When is measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized trials? Ann Intern Med. 2006;144:850-5. [PMID: 16754927] LinkGoogle Scholar13. Tirziu D, Giordano FJ, Simons M. Cell communications in the heart. Circulation. 2010;122:928-37. [PMID: 20805439] CrossrefMedlineGoogle Scholar14. McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, et al. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation. 2004;109:3050-5. [PMID: 15184287] CrossrefMedlineGoogle Scholar15. Paoletti E, Amidone M, Cassottana P, Gherzi M, Marsano L, Cannella G. Effect of sirolimus on left ventricular hypertrophy in kidney transplant recipients: a 1-year nonrandomized controlled trial. Am J Kidney Dis. 2008;52:324-30. [PMID: 18585837] CrossrefMedlineGoogle Scholar16. Turka LA, Caplan A. What is the evidence for our standards of care? J Clin Invest. 2011;121:2530. [PMID: 21737884] CrossrefMedlineGoogle Scholar17. Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med. 2010;363:1397-409. [PMID: 20660394] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From National Heart, Lung, and Blood Institute, Bethesda, MD 20892.Disclaimer: The views in this essay reflect those of the author and do not necessarily reflect those of the National Heart, Lung, and Blood Institute.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-1705.Corresponding Author: Michael S Lauer, MD, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 8128, Bethesda, MD 20892; e-mail, [email protected]nih.gov. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening Asymptomatic Adults With Resting or Exercise Electrocardiography: A Review of the Evidence for the U.S. Preventive Services Task Force Roger Chou , Bhaskar Arora , Tracy Dana , Rongwei Fu , Miranda Walker , and Linda Humphrey Metrics Cited byPopulation Prevalence and Correlates of Prolonged QT Interval: Cross-Sectional, Population-Based Study From Rural UgandaCardiac Screening With Electrocardiography, Stress Echocardiography, or Myocardial Perfusion Imaging: Advice for High-Value Care From the American College of PhysiciansRoger Chou, MD, for the High Value Care Task Force of the American College of Physicians*Time to Bring the “Electrocardio-ome” Into Modern Cardiovascular Epidemiology?∗Advancing the paradigm for cardiovascular imaging research 20 September 2011Volume 155, Issue 6Page: 395-397KeywordsBlood pressureCholesterolClinical trialsCoronary heart diseaseElectrocardiographyExerciseHypertensionLungs ePublished: 20 September 2011 Issue Published: 20 September 2011 PDF downloadLoading ...
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