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June 1, 1989CirculationOpen Access

Effects of aspirin and prostaglandin E1 on in vitro thrombolysis with urokinase. Evidence for a possible role of inhibiting platelet activity in thrombolysis.

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Why the study?

Does the addition of aspirin or prostaglandin E1 to urokinase improve thrombolysis of combined platelet and fibrin thrombi in vitro?

Population

In vitro combined platelet and fibrin thrombi produced by adding CaCl2 and collagen to citrated…

Comparison

Aspirin or prostaglandin E1 combined with… vs Urokinase alone

Design

Preclinical

Authors

WTWolfram TerresCedars-Sinai Medical CenterCBC. BeythienEppendorf (Germany)WKW. KüpperMedizinische Hochschule Hannover

Discussion

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Implication

Should not change thrombolysis practice; leaves open whether aspirin or PGE1 augments urokinase in vivo.

Structured PICO

Does the addition of aspirin or prostaglandin E1 to urokinase improve thrombolysis of combined platelet and fibrin thrombi in vitro?

P
Population
In vitro combined platelet and fibrin thrombi produced by adding CaCl2 and collagen to citrated platelet-rich plasma (250,000 platelets per microliter)
I
Intervention
Aspirin (10-200 micrograms/ml) or prostaglandin E1 (1-100 mumol/l) combined with urokinase (500-10,000 units/ml)
C
Comparator
Urokinase alone
O
Outcome
Thrombolysis (measured by dose-dependent weight loss of the thrombi)surrogate

In vitro thrombolysis of combined platelet and fibrin thrombi with urokinase is enhanced by inhibiting platelet activity with aspirin or prostaglandin E1.

Cite This Study

Terres et al. (1989) studied this question.

synapsesocial.com/papers/6a729ae331a3df82432a2d03https://doi.org/10.1161/01.cir.79.6.1309

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.1975 · 865 citations
  2. 2Aspirin kinetics and platelet aggregation in man1983 · 70 citations
  3. 3A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction1974 · 519 citations
  4. 4Dose-Related Kinetics of Aspirin1984 · 558 citations
  5. 5Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina1983 · 1,713 citations