Why the study?
Does the addition of aspirin or prostaglandin E1 to urokinase improve thrombolysis of combined platelet and fibrin thrombi in vitro?
Population
In vitro combined platelet and fibrin thrombi produced by adding CaCl2 and collagen to citrated…
Comparison
Aspirin or prostaglandin E1 combined with… vs Urokinase alone
Design
Preclinical
Authors
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Should not change thrombolysis practice; leaves open whether aspirin or PGE1 augments urokinase in vivo.
Does the addition of aspirin or prostaglandin E1 to urokinase improve thrombolysis of combined platelet and fibrin thrombi in vitro?
In vitro thrombolysis of combined platelet and fibrin thrombi with urokinase is enhanced by inhibiting platelet activity with aspirin or prostaglandin E1.
Terres et al. (1989) studied this question.
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