July 7, 2011Clinical and Experimental Pharmacology and Physiology

Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart

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Population

Female heterozygous (mRen-2)27 rats, transgenic for the mouse renin gene, and Sprague-Dawley rats

Comparison

Aliskiren alone or in combination with perindopril vs Perindopril (0.2 mg/kg per day) alone

Design

Preclinical

Authors

DCDuncan J. CampbellHeart Failure & Transplant YZYuan ZhangCentral Committee of the Communist Party of China DKDarren J. KellyConference Board

Discussion

Member takes

Implication

Should not change clinical practice; leaves open whether aliskiren's bradykinin effects translate to human outcomes.

Structured PICO

Population

Female heterozygous (mRen-2)27 rats, transgenic for the mouse renin gene, and Sprague-Dawley rats

Intervention

Aliskiren (10 mg/kg per day or 3 mg/kg per day) alone or in combination with perindopril (0.2 mg/kg per day)

Comparator

Perindopril (0.2 mg/kg per day) alone

Outcome

Angiotensin and bradykinin peptide levels, and tissue kallikrein mRNA levels in the heartsurrogate

Aliskiren increases cardiac bradykinin levels independently of renin inhibition, which is associated with increased tissue kallikrein gene expression.

Cite This Study

Campbell et al. (2011) studied this question.

synapsesocial.com/papers/6a729e54ac440176ef2ac413 https://doi.org/10.1111/j.1440-1681.2011.05572.x

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