Key result
Organic nitrates remain vital for ischemic disease and heart failure despite unresolved tolerance mechanisms.
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N itroglycerin (GTN) and other organic nitrates are impor- tant drugs commonly used in cardiovascular medicine, and, more recently, in obstetrics as tocolytic agents. Despite their clinical importance in the therapy of ischemic heart disease and heart failure, many aspects of the pharmacology of organic nitrates, including the mechanism(s) of tolerance, remain unclear.
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Gori et al. (2002) studied this question. Organic nitrates such as nitroglycerin are vital for treating ischemic heart disease and heart failure, though the mechanisms underlying nitrate tolerance remain unclear.
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