Why the study?
Does strength training compared to endurance exercise limit blood volume expansion in rats post-myocardial infarction?
Does strength training compared to endurance exercise limit blood volume expansion in rats post-myocardial infarction?
In a rat model of myocardial infarction, strength training favorably limited post-MI total blood volume and plasma expansion compared to endurance exercise.
May favor strength over endurance training to limit post-MI volume expansion in rats; leaves open human translation.
After myocardial infarction (MI), cardiac remodeling causes sodium‐induced plasma expansion (PE), contributing to ventricular dilation. Evidence suggests Post‐MI endurance exercise (END) improves cardiac function (CF). However, it is known that END causes albumin (ALB)‐induced PE, a normal training adaptation. This may not be beneficial to an infarcted heart as it may worsen the MI‐induced PE. In contrast, strength training (ST) may increase myocardial strength without causing ALB‐induced PE. The aim of this study was to investigate the effect of ST versus END on PE in the post‐MI rat hearts. MI was induced by ligating the coronary artery. Survivors were assigned to 4 groups, Sham (n=9,), MI+SED (n=9, MI+no exercise), MI+END (n=7), and MI+ST (n=10). Exercise training was initiated 1 wk post‐MI on either a rodent treadmill (END) or 85° incline ladder (ST) for 10 wks. Our results showed total blood volume (TBV) and PE (ml·100g ‐1 ) was significantly greater in MI‐END compared to MI‐ST (5.95±0.84 vs. 4.11±0.59, 3.74±0.49 vs. 2.49±0.24, p<0.05). Additionally, ALB concentration (g·dL ‐1 ) was also significantly greater in MI‐END than MI‐ST (4.59±0.52 vs. 2.75±0.28, p<0.001). Our data suggests that compared to END, ST may favorably limit post‐MI TBV and PE.
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Wason et al. (2014) studied this question.
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