Mutations of Chk2 in primary hematopoietic neoplasms

Chk2 is a novel checkpoint kinase isolated as a human homologue of yeast Cds1/Rad53.[1][1] Recent analyses have revealed that it is among key molecules signaling DNA damage via the ATM protein kinase to p53.[1][1] [2][2] Of great interest is the report that germ line mutations of the Chk2 gene are