An uninoculated batch of owl monkey kidney cell cultures yielded a viral agent 23 days after the cell culture was initiated. This agent possessed the physical, chemical, cytopathic, histological, and ultrastructural properties of a herpesvirus. Random testing of owl monkey sera showed the presence of high titered neutralizing antibodies against this new agent. Herpesvirus simplex, Herpesvirus T., Herpesvirus B, Herpesvirus suis, Herpesvirus saimiri, infectious bovine rhinotraecheitis, and Herpesvirus saguinus, OMKI 372, and OMKI 68-69 antisera failed to neutralize the infectivity of this new agent. In cell cultures the virus grew best in cells of owl monkey origin. It also grew (poorly) in cebus monkey kidney cell cultures, some batches of squirrel monkey kidney cells, in Vero, BSC-1, human embryonic lung, whole human embryo and human embryo skin and muscle cells. It failed to form plaques under an agar overlay and does not form pocks on chorioallantoic membranes of embryonated eggs. Based on these findings, the name Herpesvirus aotus has been suggested.
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Daniel et al. (1971) studied this question.