Bias and Synthesis in History

The widespread presence of micro- and nanoplastics (MNPs) in environmental matrices and consumer products has raised increasing concern about their potential effects on human health. Due to their small size, persistence, and heterogeneous physicochemical properties, MNPs may interact with biological barriers, reach different cellular compartments, and trigger organ-specific toxic responses. Among the cellular events involved, apoptosis has emerged as a recurrent mechanism linking MNP exposure to tissue injury and functional impairment. This systematic review aimed to synthesize the available