Metabolic studies in leukemia have been frequent since the first clinical applications of calorimetry. One of the first patients studied in a calorimeter (Pettenkofer and Voit, 1869, 21) had leukemia. The increased basal metabolic rate in both myeloid and lymphatic leukemia is well established and seems to be correlated with the severity of the disease. There appears to be some disagreement as to the mechanism concerned in this altered metabolism. A large group of investigators attribute the increased metabolism to changes in the abnormal cells concerned (6, 8, 10, 25, 26). Others ascribe it to effects secondary to disturbed endocrine activity (9).
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Victor et al. (1934) studied this question.