Lupus anticoagulant and antiprothrombin antibodies: embracing the future

-glycoprotein I and prothrombin are central to LAC. This article offers a historical perspective on LAC, emphasizing recent developments in antiprothrombin antibodies, their connection to LAC, and novel detection methods. Our premise is that a deeper understanding of how antiprothrombin antibodies contribute to LAC and the identification of subpopulations of these antibodies potentially responsible for it in thrombotic APS patients could lead to transformative advancements, offering new strategies for risk stratification and personalized treatments for patients with APS and beyond.