Why the study?
Does TENS and CGRP increase cutaneous blood flow in a rat musculocutaneous flap model?
Does TENS and CGRP increase cutaneous blood flow in a rat musculocutaneous flap model?
TENS and CGRP significantly increase cutaneous blood flow and extend the circulatory border in a rat musculocutaneous flap model.
The effect of blood flow on transcutaneous electrical nerve stimulation (TENS) and injection of calcitonin gene-related peptide (CGRP) was studied in a musculocutaneous flap of the rat, using laser Doppler flowmetry. The circulatory border was estimated before and after treatment. It was shown that repeated treatments with TENS gradually increased the blood flow, moving the circulatory border distally more than 100% after three treatments. Injection of NaCl into the dorsal central vein of the flap resulted in no increase in blood flow, whereas CGRP 10(-10) M increased the blood flow, so that the circulatory border moved distally 70% and 60%, respectively.
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Kjartansson et al. (1988) studied this question.
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