It is still not clear what the proteins encoded by the breast cancer susceptibility genes, BRCA1 and BRCA2 , do in the cell. In a Perspective, [Ashok Venkitaraman][1] discusses recent findings ([ Cortez et al .][2]) showing that phosphorylation of BRCA1 by a protein kinase called ATM is necessary for the cell to repair DNA damage induced by gradiation. [1]: http://www.sciencemag.org/cgi/content/full/286/5442/1100 [2]: http://www.sciencemag.org/cgi/content/short/286/5442/1162
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Ashok R. Venkitaraman (1999) studied this question.
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