The mechanisms of the motor function are studied for more than 100 years, however, they have not been established completely. Understanding those mechanisms is of great importance since the disturbances of gastrointestinal motility underlay in pathogeneses of many diseases, such as colitis, constipations, irritable bowel syndrome and others. This review is devoted to analysis of literature data of the age-related changes in the motility function of digestive tract. We have searched articles on a particular issue and have analyzed them in accordance with the parts of the digestive tract. Main attention has been paid to age-dependent functional and regulatory changes in the digestive tract. The mechanisms underlying in pathogenesis of age-related diseases of motor function of the digestive tract have not been deeply studied. Without the establishment of these mechanisms, it is impossible to create new drugs for prophylaxis and treatment of age-related disturbances in motor function of the gastrointestinal (GI) motility.
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Iefimenko et al. (2013) studied this question.
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