HERG Sequence Correction

Since our 7 July 1995 report “HERG, a human inward rectifier in the voltage-gated potassium channel family” was published ([1][1]), two previously undetected differences between our expression clone and the published nucleotide sequence ([2][2]) have been identified: T593A, yielding amino acid change V198E; and C605T, yielding P202L. These differences are thought to be the result of artifacts generated by use of the polymerase chain reaction technique. The fundamental consequence of the two mutations is a variable reduction of inward rectification. Full characterizations of the mutant and the wild type phenotypes will appear in a subsequent report. 1. 1.[↵][3] 1. M. C. Trudeau 2. et al. , Science 269, 92 (1995). [OpenUrl][4][Abstract/FREE Full Text][5] 2. 2.[↵][6] 1. J. W. Warmke, 2. B. Ganetzky , Proc. Natl. Acad. Sci. U.S.A. 91, 3438 (1994). [OpenUrl][7][Abstract/FREE Full Text][8] [1]: #ref-1 [2]: #ref-2 [3]: #xref-ref-1-1 View reference 1. in text [4]: {openurl}?query=rft.jtitle%253DScience%26rft.stitle%253DScience%26rft.issn%253D0036-8075%26rft.aulast%253DTrudeau%26rft.auinit1%253DM.%26rft.volume%253D269%26rft.issue%253D5220%26rft.spage%253D92%26rft.epage%253D95%26rft.atitle%253DHERG%252C%2Ba%2Bhuman%2Binward%2Brectifier%2Bin%2Bthe%2Bvoltage-gated%2Bpotassium%2Bchannel%2Bfamily%26rft_id%253Dinfo%253Adoi%252F10.1126%252Fscience.7604285%26rft_id%253Dinfo%253Apmid%252F7604285%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [5]: /lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6Mzoic2NpIjtzOjU6InJlc2lkIjtzOjExOiIyNjkvNTIyMC85MiI7czo0OiJhdG9tIjtzOjI2OiIvc2NpLzI3Mi81MjY1LzEwODMuMTEuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9 [6]: #xref-ref-2-1 View reference 2. in text [7]: {openurl}?query=rft.jtitle%253DPNAS%26rft.stitle%253DProc.%2BNatl.%2BAcad.%2BSci.%2BUSA%26rft.issn%253D0027-8424%26rft.aulast%253DWarmke%26rft.auinit1%253DJ.%2BW.%26rft.volume%253D91%26rft.issue%253D8%26rft.spage%253D3438%26rft.epage%253D3442%26rft.atitle%253DA%2Bfamily%2Bof%2Bpotassium%2Bchannel%2Bgenes%2Brelated%2Bto%2Beag%2Bin%2BDrosophila%2Band%2Bmammals.%26rft_id%253Dinfo%253Adoi%252F10.1073%252Fpnas.91.8.3438%26rft_id%253Dinfo%253Apmid%252F8159766%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [8]: /lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoicG5hcyI7czo1OiJyZXNpZCI7czo5OiI5MS84LzM0MzgiO3M6NDoiYXRvbSI7czoyNjoiL3NjaS8yNzIvNTI2NS8xMDgzLjExLmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==