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An environmentally benign method for O‐tert ‐Boc protection of alcohols and phenols catalyzed by MgO–ZrO 2 nanoparticles under solvent‐free conditions is described. A variety of phenols, alcohols (aliphatic and aromatic) were converted to corresponding O‐tert ‐Boc products in good to excellent yield (50–95%). The present protocol is expedient, simple, and efficient under solvent‐free conditions. The MgO–ZrO 2 Nps are easily prepared from inexpensive precursors, and are reusable, recyclable and chemoselective.
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Gawande et al. (2012) studied this question.
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