Why the study?
Does infusion of resveratrol or piceatannol alter electrophysiologic properties in a rabbit whole-heart model of atrial fibrillation?
Does infusion of resveratrol or piceatannol alter electrophysiologic properties in a rabbit whole-heart model of atrial fibrillation?
Resveratrol and piceatannol demonstrate acute antiarrhythmic electrophysiologic effects, including increased atrial refractory period and slowed conduction, in a rabbit model of AF.
Hypothesis-generating for resveratrol analogues in AF; human trials required before any clinical consideration.
The natural polyphenol resveratrol and its analogue piceatannol have various beneficial effects including antiarrhythmic properties. The aim of the present study was to examine potential electrophysiologic effects in an experimental whole-heart model of atrial fibrillation (AF). Simultaneous infusion of resveratrol (50 μmol/L) or piceatannol (10 μmol/L) in rabbit hearts resulted in an increase in atrial refractory period. Both agents induced a significant slowing of atrial conduction and of intrinsic heart rate. In both groups, a trend toward a reduction in AF and a regularization of AF was observed.
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Frommeyer et al. (2018) studied this question.
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