Severe Neonatal Alloimmune Thrombocytopenia due to Anti‐HPA‐3a

Background and Objectives: Neonatal alloimmune thrombocytopenia is usually attributable to HPA‐la antibodies. We report a case of parental platelet antigen incompatibility associated with a severe neonatal thrombocytopenia secondary to alloimmunization to HPA‐3a. Materials and Methods: Platelet antibodies were detected by the monoclonal antibody‐specific immobilization of platelet antigens, genotyping of the platelets by PCR, and HLA typing by serologic procedures and PCR. Results: Genotyping of maternal and paternal platelets confirmed the incompatibility in the HPA‐3a system. It is noteworthy that the mother is of the HLA type DRB3*0101, is ABO‐incompatible with her husband, and also has HLA class I antibodies. Conclusion: Severe neonatal thrombocytopenia associated with HPA‐3a alloimmunization is infrequent and all the factors mentioned above could have played a role in the severity of the disease.