Injection of salmon calcitonin into rats caused a significant increase in the excretion of sodium and water in a dose as small as 4 × 10 −9 g. There appeared to be a linear relationship between sodium excretion and the log dose of calcitonin. Potassium excretion and free-water clearance were not significantly affected. Thyroparathyroidectomized rats showed no impairment in their ability to excrete sodium either before or after saline loading.
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Keeler et al. (1970) studied this question.
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