Soy Phytoestrogens on DNA Methylation in Prostate Cancer

This is the authors' abstract. We don't add key points for this paper.

Citation: Daures M, Ngollo M, Idrissou M, et al. Soy Phytoestrogens on DNA Methylation in Prostate Cancer. J Clin Epigenet. 2017, 3:1. Soy phytoestrogens are dietary components with considerable effects on reducing the incidence of prostate cancer. Furthermore, the epigenetic regulation of gene expression can be modified by soy phytoestrogens [1]. Qualitative and quantitative studies show a decrease of promoter methylation on tumour suppressor gene such as BRCA1, BRCA2, EPHB2, GSTP1 and RASSF1A on prostate cancer cell lines treated with genistein and daidzein. Effects of both molecules were compared to the demethylating agent of DNA, the 5-azacytidin [2,3]. Indeed, these genes are known to be hypermethylated in prostate cancer. This hypermethylation leads to the loss of their expressions and to chemotherapy-resistance of tumor cells [4,5].