The preparation and characterization of a new tetramercaptocalix[4]arene and its 211At complex is described. The in vivo stability of the complex has been evaluated in nude mice for the purpose of α-radioimmunotherapy of cancer. The study shows that while this complex lacks adequate stability in vivo, 211At may behave as a heavy metal ion and may be successfully sequestered for biomedical applications.
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Yordanov et al. (2000) studied this question.
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