Key result
Sickle cell trait is evaluated for altering the relationship between HbA1c and average glucose.
Observational
Answers are grounded in this paper and cite their sources.
Hemoglobin A1c has a predictable correlation to blood glucose, and is used to estimate average glucose for the previous 2-3 months.1 Hemoglobin variants may invalidate HbA1c results in vitro by analytical interference or in vivo by altering RBC lifespan or glycation rate. Several researchers have examined analytical reproducibility in heterozygous Hemoglobin AS (HbAS) samples, i.e. from subjects with sickle cell trait (SCT), and determined which assays provide reproducible results.2-5 No study to date has compared HbA1c to 3 months of glucose measurements in persons with SCT and diabetes. We asked if the correlation between HbA1c and average glucose was altered by the presence of SCT.
No takes yet. Share an insight, caveat, or question.
Behan et al. (2015) conducted an observational in Sickle cell trait and diabetes. Sickle cell trait (heterozygous Hemoglobin AS) was evaluated on Correlation between HbA1c and 3-month average blood glucose.
Synapse has enriched 10 related papers. Consider them for comparative context: