Apoferritin-encapsulated Pt nanoparticles (AFt–Pt) were bio-mimetically prepared by an in situreduction method in the unique 8 nm spherical cage of apoferritin. The average size of AFt–Pt was 4.3 ± 0.9 nm. The spherical structure of apoferritin remained intact after loading Pt particles in its cavity. Apoferritin coating increased the amount of Pt internalized in HepG2 cells by about three times viareceptor-mediated endocytosis. AFt–Pt showed greatly improved biocompatibility compared with polyvinylpyrrolidone stabilized Pt nanoparticles (PVP–Pt). More than 80% of cells survived after treatment with 100 μM AFt–Pt for 48 h. By camouflaging the particles with a protein corona, apoferritin conferred a cell-recognizable identity to the particles, which strikingly ameliorated the bio-effects of the nanoparticles.
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Liu et al. (2011) studied this question.
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