Why the study?
Does paraplegia alter cardiac electrophysiology and Ca2+ regulatory proteins to increase susceptibility to ventricular arrhythmias in rats?
Population
Male Wistar rats (intact n=18, paraplegic n=14)
Comparison
Paraplegia model vs Intact (control) rats
Design
Preclinical
Authors
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May heighten arrhythmia risk via Ca2+ changes in rats; leaves open human relevance after spinal cord injury.
Does paraplegia alter cardiac electrophysiology and Ca2+ regulatory proteins to increase susceptibility to ventricular arrhythmias in rats?
Paraplegia in rats enhances cardiac electrophysiological properties and alters Ca2+ regulatory proteins, increasing susceptibility to ventricular arrhythmias.
Rodenbaugh et al. (2003) studied this question.
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