Key result
All-trans-retinoic acid reduces plasma lipids, improves aortic lesions, and suppresses platelet activation in atherosclerotic rabbits.
RCT
Randomly allocated
BACKGROUND: All-trans-retinoic acid (atRA) is effective for many proliferative diseases. We investigated the protective effects of atRA against atherosclerosis. METHODS: Rabbits were randomly allocated to receive basal diet or an HFD for 4 weeks. HFD group then received rosuvastatin (3 mg/day), atRA (5 mg/kg/day), or the same volume of vehicle, respectively, for next 8 weeks. RESULTS: HFD group showed increases in plasma lipids and aortic plaque formation. P-selectin expression and fibrinogen binding on platelets or deposition on the intima of the aorta also increased significantly as did the levels of TNF-α, IL-6, and fibrinogen in plasma. After 8 weeks of treatment with atRA, there was a significant decrease in plasma lipids and improvement in aortic lesions. AtRA also inhibited the expression of P-selectin and fibrinogen binding on platelets and deposition on the intima of the aorta. CONCLUSION: AtRA can ameliorate HFD-induced AS in rabbits by inhibiting platelet activation and inflammation.
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Zhou et al. (2012) conducted an RCT in High fat diet-induced atherosclerosis. All-trans-retinoic acid (atRA) vs. Rosuvastatin (3 mg/day) or vehicle was evaluated on Plasma lipids, aortic lesions, platelet activation (P-selectin expression and fibrinogen binding), and inflammation (TNF-α, IL-6, fibrinogen). All-trans-retinoic acid (5 mg/kg/day for 8 weeks) significantly decreased plasma lipids, improved aortic lesions, and inhibited platelet activation in rabbits with high-fat diet-induced atherosclerosis.
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